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Is titanium dioxide safe?
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At the present JECFA meeting, the committee considered additional toxicological studies relevant to the safety assessment of the chemical that investigated its toxicokinetics, acute toxicity, short-term toxicity, long-term toxicity and carcinogenicity, genotoxicity, and reproductive and developmental toxicity, as well as special studies addressing its short-term initiation/promotion potential for colon cancer. The experts acknowledged that a large number of toxicological studies have been conducted using test materials, including nanoparticles, having size distributions and physico-chemical properties not comparable to real-world uses of titanium dioxide as a food additive. The studies on non-representative materials were evaluated by JECFA, but the committee concluded that such studies are not relevant to the safety assessment of the additive.
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Testing samples were made mixing 100 uL of TiO2NPs suspensions (0.2 mg/mL and 0.02 mg/mL) and vitamins@P25TiO2NPs (0.2 mg/mL and 0.02 mg/mL) with 100 μL ATCC 29,213 methicillin-sensitive Staphylococcus aureus (MSSA) (107 in PBS, pH 7). Controls were made replacing nanoparticles with the same volume of PBS. The concentrations of nanoparticle suspensions were chosen based on the FDA approved maximal and the minimal amount usually found in sunscreens, which are 20% and 2% (this is equivalent to 0.2 mg/mL and 0.02 mg/mL for nanoparticles suspensions). The cream concentration, on the other hand, was an intermediate value of 10%.
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≤0.3
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SYNONYMES (LISTE NON EXHAUSTIVE)
There are many uses of titanium dioxide that we don't know about because they were made exempt from being on the package in 1977, said Faber, who added that nothing much has changed since – other than the FDA approving some other uses of the color additive, such as expanding the use of mica-based pearlescent pigments (prepared from titanium dioxide) as color additives in distilled spirits over recent years.
CAS: 1345-05-7
Titanium alloy is widely used as a biomaterial due to its superior biocompatibility, mechanical properties close to human bones, and enhanced corrosion resistance. These properties have made the alloys suitable for use in a wide spectrum of biomedical applications including artificial bones, artificial joints, dental roots, and medical devices. The excellent performance of titanium alloy is mainly due to the oxide film as shown in Figure 1 [1]. The functional composition of the oxide film is mainly titanium dioxide (TiO2). Titanium dioxide has good biocompatibility, stable chemical property, and low solubility in water, which prevents substrate metal ions from dissolution. Furthermore, it also improves the wear and fatigue resistance of implants in the human body.
The toxicity of P25TiO2NPs under UV radiation could be even higher when combined with other usual components of sunscreens Indeed, Soler de la Vega et al. advise that combination with parabens increases the toxicity of the final cosmetic mixture [53].

The Future of Titanium Dioxide: A Glimpse to 2023

CSPI’s Chemical Cuisine is the web’s definitive rating of the chemicals used to preserve foods and affect their taste, texture, or appearance. Besides titanium dioxide, the group recommends avoiding artificial sweeteners like aspartame, acesulfame potassium, and sucralose, as well as synthetic food dyes like Yellow 5 and Red 3. CSPI and others have recently asked the Food and Drug Administration to ban the latter dye in foods and ingested drugs because the FDA has already determined that it is a carcinogen unsafe for use in cosmetics.
Chinese anatase titanium dioxide has become a popular topic in the field of materials science due to its unique properties and wide range of applications. Anatase titanium dioxide is a type of titanium dioxide with the chemical formula TiO2, and is known for its high refractive index, excellent UV resistance, and good photocatalytic activity.
Titanium alloy is widely used as a biomaterial due to its superior biocompatibility, mechanical properties close to human bones, and enhanced corrosion resistance. These properties have made the alloys suitable for use in a wide spectrum of biomedical applications including artificial bones, artificial joints, dental roots, and medical devices. The excellent performance of titanium alloy is mainly due to the oxide film as shown in Figure 1 [1]. The functional composition of the oxide film is mainly titanium dioxide (TiO2). Titanium dioxide has good biocompatibility, stable chemical property, and low solubility in water, which prevents substrate metal ions from dissolution. Furthermore, it also improves the wear and fatigue resistance of implants in the human body.

