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The FDA first approved the use of titanium dioxide in food in 1966, following its 1960 removal (along with the removal of other color additives) from the agency's original Generally Recognized as Safe list. In 1977, titanium dioxide joined the list of color additives that are exempt from certification, which means titanium dioxide doesn't have to be listed on the packaging of every product it's used in, Faber noted.

According to the EFSA's Expert Panel on Food Additives and Flavorings 2021 opinion regarding titanium dioxide, it could not rule out a concern for genotoxicity from ingestion of the material based on a perceived gap in data on this risk, which serves as the basis for current ban, said a March report on the decision.
Lithopone, a white pigment composed of a mixture of zinc sulfide and barium sulfate, has become an indispensable ingredient in the paint industry. Its unique properties, including excellent opacity, high brightness, and resistance to weathering, make it highly valued among paint manufacturers. As the demand for sustainable and efficient paint products grows, the role of lithopone and its suppliers has become more critical than ever.


Top 10 Chinese TiO2 exporters in 2016
It's also worth noting that even prior to the EU decision, France had already outlawed titanium dioxide in food back in January 2020.
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In conclusion, the CaCO3 and TiO2 factory plays a vital role in supporting industrial and economic development by producing high-quality materials for a wide range of applications. The continued growth of industries such as construction, agriculture, and manufacturing relies on the availability of CaCO3 and TiO2 from reliable sources like the factory. As technology advances and demand increases, the factory will continue to innovate and expand its production capacity to meet the needs of a rapidly changing world.
The whole scientific experimental design in some of these studies is very flawed, Kaminski said.
In a study published in the journal Toxicology, researchers examined the effects of exposing human colon cancer cell line (HTC116) titanium dioxide food additives in vitro. “In the absence of cytotoxicity, E171 was accumulated in the cells after 24 hours of exposure, increasing granularity and reactive oxygen species, inducing alterations in the molecular pattern of nucleic acids and lipids, and causing nuclei enlargement, DNA damage and tubulin depolymerization,” the scientists wrote. Researchers removed the additive from the culture, then examined the results 48 hours later. They found, “The removal of E171 was unable to revert the alterations found after 24 h of exposure in colon cells. In conclusion, exposure to E171 causes alterations that cannot be reverted after 48 h if E171 is removed from colon cells.”
The other form in which titanium dioxide is produced is as an ultrafine (nanomaterial) product. This form is selected when different properties, such as transparency and maximum ultraviolet light absorption, are needed, such as in cosmetic sunscreens.
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Lithopone has therefore traditionally been used in stoppers and putties, jointing compounds and sealing compounds, primers and undercoats and in road-marking paints.


The FDA continues to allow for the safe use of titanium dioxide as a color additive in foods generally according to the specifications and conditions, including that the quantity of titanium dioxide does not exceed 1% by weight of the food, the FDA said in a statement to USA TODAY.
Titanium dioxide (TiO2). Titanium dioxide is the most common white pigment used today. As a pigment, titanium dioxide is unique because it combines both high colouring and high opacifying capacity. This is mainly due to its high refractive index (2.7). Furthermore, titanium dioxide is an excellent UV absorber (it is used in sun protective creams). Some typical properties are: density 3.3-4.25 g/cm3; pH of water suspension 3.5-10.5; particle size 8–300 nm; oil absorption 10–45 g/100 g; specific surface area 7–160 m2/g. Most titanium dioxide is produced from the rutile (TiO2) or ilmenite (titanate of ferrous iron). Titanium dioxide can be obtained using different processes.