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450 - Introduction
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Furthermore, the factory's investment in research and development allows it to stay ahead of the curve in terms of innovation. By continuously exploring new possibilities and improving its processes, CAS 13463-67-7 is able to offer cutting-edge titanium dioxide products that meet the evolving needs of the market.
Australia and New Zealand review of TiO2
A 2023 study published in the journal Environmental Research, scientists examined the effect of titanium dioxide nanoparticles on important gut bacteria in mice. Their results showed “the growth inhibitory effects could be associated with cell membrane damage caused by titanium dioxide nanoparticles to the bacterial strains. Metabolomics analysis showed that TiO2 NPs caused alterations in multiple metabolic pathways of gut bacteria, such as tryptophan and arginine metabolism, which were demonstrated to play crucial roles in regulating gut and host health.” The researchers also found that four different neuroprotective metabolites “were significantly reduced” in urine and in vitro bacteria and vivo urine samples. The researchers concluded: “Increasing evidence implies that the gut microbiome plays a profound role in regulating host metabolism. Our results illustrated that TiO2 NPs hindered the growth of four beneficial gut bacterial strains.”

Toxic effects of TiO2 NPs on soil organisms
Some food products will include titanium dioxide on their nutrition label. But again, it can be hard to tell for those who don't list the ingredient.
So if you’re worried about titanium dioxide, don’t be! With current research and industry recommendations, titanium dioxide is a safe food additive. And if you want to avoid it, that’s ok too! Just don’t expect certain foods to be so white, smooth, and bright.
Lithopone 30% increases extruder performance and reduces processing costs, improves quality and is suitable for masterbatch for injection of Polyolefins, ABS, Polycarbonate, Polypropylene, Polyethylene, Polystyrene, single layer films, multi-layer films and for white, coloured and filled masterbatch. The combination of Lithopone 30 with TiO2 results in improved mechanical properties including higher elongation values and better impact resistance.
The FDA and certain others say titanium dioxide is safe to use in foods and personal care products. The FDA provides strict guidelines on how much can be used in food. The limit is very small: no more than 1% titanium dioxide.
Lithopone has therefore traditionally been used in stoppers and putties, jointing compounds and sealing compounds, primers and undercoats and in road-marking paints.
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Health effects
When E171 isn’t combined with other ingredients and administered in water, some studies suggest that under these artificial conditions, E171 may be processed differently in the body resulting in some biological changes in experimental animals that are poorly understood.
Titanium dioxide is often listed in the ingredients list on the product label when used in home, beauty and personal care products.