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It's also worth noting that even prior to the EU decision, France had already outlawed titanium dioxide in food back in January 2020.

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As a food additive, titanium dioxide and its nanoparticles in particular have been associated with DNA damage and cell mutations, which in turn, have potential to cause cancer. When used as a food coloring, it is known as E171.

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Acknowledgments

The titanium dioxide (TiO2) industry supplier plays a crucial role in providing this essential material for a wide range of applications. TiO2 is a white pigment that is commonly used in paints, coatings, plastics, and paper, among other industries. The demand for TiO2 continues to grow as it is an important ingredient in products that require opacity, brightness, and UV protection.

It's hard to determine the total amount of food products that have titanium dioxide because federal regulations don't require all producers to list its use on ingredient labels, but the list of foods containing the substance certainly doesn't end with Skittles.

A study published in the Journal of Agricultural and Food Chemistry in 2019 sought to examine the effects of titanium dioxide on intestinal inflammation. Researchers did this by feeding rats titanium dioxide nanoparticles and found that, after the course of two to three months, the animals had lower body weights and induced intestinal inflammation. The researchers also found the nanoparticles altered gut microbiota composition and aggravated chronic colitis. The rats also experienced reduced populations of CD4+T cells (which are cells that help organize immune responses by prompting other immune cells to fight infection), regulatory T cells, and white blood cells in mesenteric lymph nodes. The researchers wrote: “Dietary TiO2 nanoparticles could interfere with the balance of the immune system and dynamic of gut microbiome, which may result in low-grade intestinal inflammation and aggravated immunological response to external stimulus, thus introducing potential health risk.”

Titanium dioxide is used in an enormous range of food products, which can feel jarring when looking at some of its other uses.

Still, in 2016 Skittles publicly declared it would get rid of the chemical compound in its products, according to a press release at the time from the Center for Food Safety, which called the substance harmful and potentially poisonous. But the ingredient remains, according to the lawsuit, which alleges the candy company is misleading consumers by not having eliminated titanium dioxide.

Prof. Maged Younes, Chair of EFSA’s expert Panel on Food Additives and Flavourings (FAF), wrote of the decision: “Taking into account all available scientific studies and data, the Panel concluded that titanium dioxide can no longer be considered safe as a food additive. A critical element in reaching this conclusion is that we could not exclude genotoxicity concerns after consumption of titanium dioxide particles. After oral ingestion, the absorption of titanium dioxide particles is low, however they can accumulate in the body.”

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Titanium dioxide exists primarily in three crystalline forms rutile, anatase, and brookite. Among these, anatase is characterized by its unique electronic properties and higher photocatalytic activity, making it suitable for applications requiring enhanced light absorption and reactivity. Its ability to act as a photocatalyst enables the breakdown of organic pollutants, making it a valuable component in environmental remediation strategies.