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- Hydroxypropyl methylcellulose finds its primary use as a viscosity modifier and thickening agent in numerous products. In the pharmaceutical industry, it is used as a binder in tablet formulations, ensuring uniformity in the manufacturing process. Its ability to form a gel when mixed with water also makes it an essential ingredient in controlled-release drug delivery systems.
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Cellulose is the most frequent polysaccharide in nature consisting of (some hundreds up to ten thousands) β-glycosidic linked glucose molecules. It is the main constituent of plant cell walls and vegetable fibre. It occurs mostly associated with hemicelluloses and lignin. It is therefore a common component of plant-based feed for all food producing and companion animals. However, these animals are not capable to digest cellulose enzymatically due to the lack of cellulases. The monomer element of cellulose, glucose, will not be released from cellulose. But gastrointestinal microbes can split cellulose, the main degradation products are short-chain fatty acids. In a simplified view, monogastric animals cannot digest cellulose, small amounts are microbially degraded in the large intestine. Minor amounts of cellulose may be absorbed as such by paracellular transport (passing through the intercellular space) or by transcytosis (transcellular transport of macromolecules captured in vesicles). On the other side, animals with large fermentation chambers in the intestine, such as ruminants, horses and rabbits, utilise large amounts of cellulose as energy source. In summary, cellulose is a natural part of feed and plays a physiological role in nutrition of animals (see Section 3.2.1).
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Intraocularly, hpmc is used as a volume substitute for the aqueous humor to maintain anterior segment integrity and anatomical spaces during intraocular interventions, to protect intraocular tissues (i.e. the corneal endothelium), to sustain corneal transparency as well as for the lubrication of intraocular lenses (IOL) and surgical instruments.
- One of the most significant advantages of using HPMC in gypsum plaster is its ability to improve flexibility


1. HPMC VS HEC: DS

Due to its water solubility, HPMC gel is often used in the formulation of sunscreen products to enhance their water resistance and overall performance.
Safety profile of HPMC (E464)
HPMC is also used by treating polymers with hydrochloric acid and then subjecting them to high temperatures. HPMC has been used for decades as an additive in pharmaceuticals and personal care products. HPMC is also used as an ingredient in many foods. Due to semi-synthetic manufacturing procedures, hypromellose is slightly more expensive to produce than gelatin because it is a vegetarian alternative but is a better choice for our bodies.


The European Commission received a request from Association Management & Regulatory Services Ltd2 for re-evaluation of the product hydroxypropyl methyl cellulose, when used as a feed additive for all animal species (category: technological additives; functional groups: emulsifier, stabilizer, thickener, gelling agent or binder).
