A 2023 study published in the journal Particle and Fibre Toxicology set out to examine the impact of titanium dioxide nanoparticles in mice “on the course and prognosis of ulcerative colitis,” by creating an ulcerative colitis disease model. Researchers found that the titanium dioxide nanoparticles significantly increased the severity of colitis. They also “decreased the body weight, increased the disease activity index and colonic mucosa damage index scores, shortened the colonic length, increased the inflammatory infiltration in the colon.” Researchers concluded: “Oral intake of TiO2 nanoparticles could affect the course of acute colitis in exacerbating the development of ulcerative colitis, prolonging the ulcerative colitis course and inhibiting ulcerative colitis recovery.”
For that reason, the Center for Science in the Public Interest has graded titanium dioxide as a food additive that consumers should seek to “avoid.” Scientists at the nonprofit nutrition and food safety watchdog group today published a new entry for titanium dioxide in its Chemical Cuisine database of food additives.
Titanium dioxide makes products, like toothpaste, white and bright. It's also used in makeup, sunscreen, plastic, and paint. (Photo Credit: iStock/Getty Images)
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Overall, the Food Directorate's comprehensive review of the available science of TiO2 as a food additive showed:
Solids were stable and did not show visible signs or changes in their spectra after being kept at room temperature for over 60 days. The absorbance at the maximum absorbance wavelength remained unmodified.
Safety[edit]
Lithopone, a white pigment composed of a mixture of barium sulfate and zinc sulfide, is commonly used in the leather industry as a coloring agent. Leather suppliers around the world rely on lithopone to achieve the desired color and finish on their products.
Some of the most well-known manufacturers include DuPont, Cristal Global, and Huntsman Corporation Some of the most well-known manufacturers include DuPont, Cristal Global, and Huntsman Corporationhoney bun ingredients titanium dioxide manufacturers. These companies have a long history of producing high-quality titanium dioxide products that are safe for human consumption. 
When manufacturers add titanium dioxide to foods and other ingestible products, it’s typically referred to as E171, which relates to food-grade purity.
Food safety experts in the European Union (EU) have recently updated their safety assessment of TiO2 as a food additive. In Europe, TiO2 is referred to as E171, in accordance with European labelling requirements for food additives. The EU expert panel took into account toxicity studies of TiO2 nanoparticles, which to this point had not been considered relevant to the safety assessment of TiO2 as a food additive.
As a widely used substance with multiple applications, research is being carried out to improve the production process to reduce the levels of chemicals used and waste produced, and to recycle any by-products.
There seems to be a lot of misunderstanding about titanium dioxide, which can be used as a colorant in foods. While headlines may suggest titanium dioxide is a health concern, scientific research has actually shown titanium dioxide to be safe. So what is it used for and why is it used? Read on to learn more!