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- The molecular weight of HEC can vary, which significantly influences its properties and uses. Low molecular weight HEC is more soluble, while high molecular weight types provide better thickening effects. The percentage of hydroxyethyl substitution also plays a crucial role, impacting viscosity and other rheological properties.
- HEC is widely used in hair care products due to its ability to provide conditioning and moisturizing effects. It forms a protective layer on the hair shaft, reducing frizz and improving manageability. Additionally, HEC's ability to retain moisture makes it an ideal ingredient for hair masks and conditioners.
- In conclusion, the Material Safety Data Sheet of hydroxypropyl methyl cellulose serves as a valuable resource for understanding the potential hazards and safe handling procedures associated with this substance. By following the guidelines outlined in the MSDS, individuals can work safely with HPMC and minimize the risks of exposure. As with any chemical substance, it is crucial to always prioritize safety and take necessary precautions when handling hydroxypropyl methyl cellulose in any industrial or commercial setting.
- Customer satisfaction is at the core of HPMC Company's business philosophy. The company takes pride in its ability to provide high-quality products, exceptional customer service, and timely delivery to its customers. HPMC Company values its relationships with its customers and works closely with them to understand their needs and provide solutions that meet their requirements.
HPMC also acts as a retarder, preventing premature hardening, and improves the adhesion of coatings and paints, making them more resistant to cracking and water damage HPMC also acts as a retarder, preventing premature hardening, and improves the adhesion of coatings and paints, making them more resistant to cracking and water damageuses of hydroxypropyl methylcellulose. 
What else is HPMC used for?
There are data for microcrystalline cellulose (E 460), methyl cellulose (E 461), hydroxypropyl cellulose (E 463) and sodium carboxymethyl cellulose (E 466), which were tested in mice, rats, hamsters and/or rabbits with oral dosing or via gavage. As regards microcrystalline cellulose (E 460) studies have been conducted in rats (dietary exposure) with a mixture including guar gum or sodium carboxymethylcellulose (E 466) (15% in either case). The NOAEL for both maternal and developmental toxicity were the highest experimental dosages, i.e. 4,500 mg/kg bw (for mixture with guar gum) and 4,600 mg/kg bw (for mixture with sodium carboxymethyl cellulose). Methyl cellulose (E 461) was examined in mice, rats, hamsters and rabbits. In two different studies, pregnant mice were exposed via gavage (vehicle corn oil) to a dose range of 16-1,600 mg methyl cellulose (E 461)/kg bw per day from day 6 to 15 of gestation, followed by a caesarean section at day 17 of gestation. In the first study, maternal toxicity (increase in mortality and reduced pregnancy rate in the survivors) as well as retarded ossification in fetuses were noticed at the highest tested level, pointing to a NOAEL of 345 mg methyl cellulose (E 461) mg/kg bw per day (the last but one highest dosage) in mice. In the second study, no maternal toxicity and fetal abnormalities were observed in mice exposed up to 700 mg methyl cellulose (E 461) mg/kg bw per day. Rat studies (n = 2) were performed in pregnant dams exposed via gavage (vehicle corn oil) to a dose range of 16-1,320 mg methyl cellulose (E 461) mg/kg bw per day from day 6 to 15 of gestation followed by a caesarean section at day 20. In the first study (0, 13, 51, 285 or 1,320 mg methyl cellulose (E 461)/kg bw per day) the highest tested dosage resulted in no maternal toxicity but also in increased incidence of extra centres of ossification in vertebrae of fetuses from high dose dams; in a second rat study, the incidence of such alteration slightly increased in fetuses from the highest dosed group (1,200 mg methyl cellulose (E 461)/kg bw per day). Based on the above results, a NOAEL of 285 mg methyl cellulose (E 461) mg/kg bw per day could be identified in rats. No maternal or fetal toxicity was detected in Golden hamsters exposed via gavage (vehicle corn oil) up to 1,000 mg methyl cellulose (E 461) mg/kg bw per day from day 6 to 10 of gestation followed by a caesarean section at day 20. The study on rabbits was discarded due to poor experimental design. The only relevant developmental toxicity study with hydroxypropyl cellulose (E 463) (dissolved in 1% gum arabic solution) was performed in pregnant rats exposed via gavage from day 7 to 17 of gestation to 0, 200, 1,000 or 5,000 mg/kg bw test item and some of them subjected to caesarean sections at day 20. No treatment-related adverse effects were detected in dams or in the examined fetuses. A number of dams were allowed to deliver and no clinical, behavioural or morphological changes were observed in the examined pups. Their reproductive ability was seemingly not affected and no abnormalities were found in the F1-derived fetuses. The in utero exposure to the highest dose (5,000 mg/kg bw per day) may be considered as the NOAEL of methyl cellulose (E 461) for this study. No mortality, and no adverse effects were observed on implantation or on fetal survival in pregnant mice or rats dosed via gavage with up to 1,600 mg sodium carboxymethyl cellulose (E 466)/kg bw per day.
These modifications alter the properties of cellulose, imparting it with water-solubility and other desirable characteristics These modifications alter the properties of cellulose, imparting it with water-solubility and other desirable characteristicswhat is hpmc made from. Hydroxypropyl methylcellulose cannot be digested by humans and passes through the digestive system.
This is because the higher degree of substitution introduces more polar groups along the polymer chain, increasing its affinity for ethanol This is because the higher degree of substitution introduces more polar groups along the polymer chain, increasing its affinity for ethanolhpmc solubility in ethanol. Similarly, a lower molecular weight allows the polymer chains to pack more loosely, making it easier for them to interact with the solvent molecules. Gypsum Hand Plaster
Ist HPMC vegan?
HPMC is especially valued for its role as a capsule shell. Traditional gelatin capsules are made from animal by-products, making them unsuitable for vegetarians and vegans. HPMC capsules, on the other hand, are completely plant-based and offer an excellent alternative that suits a wide range of dietary preferences.
The majority of the available studies have been performed in rats, just few of them in rabbits and dogs. Among those meeting the current criteria for toxicological testing, the no observed adverse effect level (NOAEL) values for the different modified celluloses were identified most often corresponding to the highest tested level or changes in body or organ weights. For microcrystalline cellulose (E 460) the identified NOAELs in rats ranged from 3,769 mg/kg body weight (bw) per day to 9,000 mg/kg bw per day and in all cases corresponded to the highest levels of the test substance. For methyl cellulose (E 461), the dose level of 3% in rats (equivalent to 2,700 mg/kw bw per day) was selected as the NOAEL based on a decrease in body and organ weight displayed in male rats administered with the top additive level (10%, equivalent to 9,000 mg/kg bw per day and day).
hpmc side effects. Anaphylaxis requires immediate medical treatment, so if you suspect you are experiencing this reaction, seek emergency medical help right away.