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- One of the main uses of hydroxyethylcellulose is as a thickening agent in personal care products such as shampoos, lotions, and creams. Its ability to increase the viscosity of products without compromising their texture or appearance makes it a valuable ingredient in the formulation of these products. In addition, hydroxyethylcellulose can also act as a stabilizer and emulsifier, helping to keep ingredients properly mixed together.
- In the cosmetic industry, HPMC is used in a variety of personal care products such as creams, lotions, and hair care products. It acts as a thickening agent, emulsifier, and film-former to improve the texture, stability, and shelf life of cosmetic formulations. HPMC is also used in sunscreen products to enhance the protection and water resistance of the sunscreen.
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But, there are some potential disadvantages that are not immediately obvious. HPMC is listed as a food ingredient — E464 — which means that recommended daily maximum quantities must be defined. HPMC undergoes a rigorous manufacturing process involving the synthetic — and not natural — alteration of cellulose. During production, various highly reactive, harmful or toxic substances are used that must be removed and disposed after production, including propylene oxide (which is considered to be carcinogenic) and chloromethane.
- The versatility of HPMC as a thickener is further enhanced by its ability to respond to changes in temperature and pH, allowing it to be tailored for specific applications. Its rheological properties can be manipulated, making it suitable for both cold and hot processing conditions.
- In conclusion, the safety of HPMC is of utmost importance in pharmaceutical manufacturing. By implementing strict quality control procedures, using high-quality raw materials, regularly inspecting and maintaining equipment and facilities, and training employees on safety protocols, manufacturers can ensure the safety of HPMC and produce high-quality pharmaceutical products that meet regulatory requirements and protect public health.
- 1. Food Industry HPMC is commonly used as a thickener in sauces, soups, and puddings, as well as a stabilizer for emulsions and suspensions.
3.2.2.1 Genotoxicity

hpmc thickener.
No specific data on the efficacy of HPMC in feedingstuffs were provided. HPMC is authorised for use as a food additive. The effect seen when used in food could reasonably be expected to be seen when ethyl cellulose is used as an additive in feed.
Cellulose wird in heißer Natronlauge gequollen und bei 50 bis 80 °C mit Propylenoxid und hohem Methylchlorid-Druck umgesetzt; Letzteres reagiert erst bei hoher Temperatur. Typische Nebenprodukte von Polykondensationen und Hydrolyse des Propylenoxids sind Propylenglycol, Di- und Tripropylenglykol sowie neben Methanol auch deren Methylether (z. B. Methoxypropanol, Dipropylenglycolmonomethylether usw.). Zur Isolierung werden zuerst alle bis 110 °C flüchtigen Stoffe abdestilliert und anschließend mit heißem Wasser alle Glycole und Salze ausgewaschen, der Feststoff getrocknet und zum Pulver vermahlen. Für den Lebensmittel- und Pharmabereich ist die Herstellung unter GMP-Bedingungen vorgeschrieben.



redispersible polymer powder manufacturing process. The drying process may involve techniques such as spray drying, freeze drying, or oven drying, depending on the specific requirements of the final product.